Sensitization and apoptosis augmentation of K562/ADM cells by anti-multidrug resistance gene peptide nucleic acid and antisense oligodeoxyribonucleotide.

@article{Wei2003SensitizationAA,
  title={Sensitization and apoptosis augmentation of K562/ADM cells by anti-multidrug resistance gene peptide nucleic acid and antisense oligodeoxyribonucleotide.},
  author={Hu-lai Wei and Yong-jie Wu and Tao Jing and De-cheng Bai and Lan-fang Ma},
  journal={Acta pharmacologica Sinica},
  year={2003},
  volume={24 8},
  pages={805-11}
}
AIM To investigate the reversal effect and apoptosis enhancement of peptide nucleic acid (PNA) and antisense oligodeoxyribonucleotide (ASODN) targeted to multidrug resistance gene (mdr1) on human multidrug resistant leukemia K562/ADM cells. METHODS A 15-mer PNA and the same sequence of ASODN, complementary to the 5' end of the AUG initiator codon… CONTINUE READING