Sensitization, kindling, and anticonvulsants in mania.

  title={Sensitization, kindling, and anticonvulsants in mania.},
  author={Robert M Post and Susan R. B. Weiss},
  journal={The Journal of clinical psychiatry},
  volume={50 Suppl},
  pages={23-30; discussion 45-7}
Cocaine can induce manic syndromes ranging from mild hypomania to severe dysphoric and psychotic mania, in part depending on the number and duration of drug administrations. Repeated cocaine administration in animals results in increased motor (behavioral sensitization) and convulsive (pharmacologic kindling) responses. Study of these progressive syndromes in animals may provide insights into principles underlying the longitudinal evolution of manic syndromes in man, including the increased… CONTINUE READING


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