Sensitivity to the effects of opioids in rats with free access to exercise wheels: µ-opioid tolerance and physical dependence

@article{Smith2003SensitivityTT,
  title={Sensitivity to the effects of opioids in rats with free access to exercise wheels: µ-opioid tolerance and physical dependence},
  author={Mark A. Smith and David L. Yancey},
  journal={Psychopharmacology},
  year={2003},
  volume={168},
  pages={426-434}
}
RationaleExercise stimulates the release of endogenous opioid peptides and increases nociceptive (i.e. pain) thresholds in both human and animal subjects. During chronic, long-term exercise, sensitivity to the effects of morphine and other µ opioids decreases, leading some investigators to propose that exercise may lead to the development of cross tolerance to exogenously administered opioid agonists.ObjectiveThe purpose of the present investigation was to examine the effects of chronic… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats.

  • Arthritis & rheumatology
  • 2017
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Persistent exercise attenuates nicotine- but not clonidine-induced antinociception in female rats

  • Pharmacology Biochemistry and Behavior
  • 2006
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES