Sensitivity to the effects of a kappa opioid in rats with free access to exercise wheels: differential effects across behavioral measures.

@article{Smith2004SensitivityTT,
  title={Sensitivity to the effects of a kappa opioid in rats with free access to exercise wheels: differential effects across behavioral measures.},
  author={Mark A. Smith and Jacob M. McClean and Paul A. Bryant},
  journal={Pharmacology, biochemistry, and behavior},
  year={2004},
  volume={77 1},
  pages={49-57}
}
It is well established that chronic exercise decreases sensitivity to mu opioid agonists; however, it is less clear what effects it has on kappa opioids. The purpose of the present study was to examine sensitivity to the effects of the selective, kappa opioid spiradoline in rats with free access to exercise wheels. Rats were obtained at weaning and randomly assigned to either standard polycarbonate cages (sedentary) or modified cages equipped with exercise wheels (exercise). After approximately… CONTINUE READING