Sensitivity to subjective effects of cocaine in drug abusers: relationship to cerebral ventricle size.

@article{Morgan1993SensitivityTS,
  title={Sensitivity to subjective effects of cocaine in drug abusers: relationship to cerebral ventricle size.},
  author={Michael John Morgan and Nicola G. Cascella and June M. Stapleton and Robert L. Phillips and Babington C-K Yung and Dean F. Wong and Elias K Shaya and Edythe D. London},
  journal={The American journal of psychiatry},
  year={1993},
  volume={150 11},
  pages={1712-7}
}
OBJECTIVE The purpose of this study was to assess the functional significance of ventricle-brain ratio (VBR) in terms of how it might affect sensitivity to cocaine, an indirect dopamine agonist. METHOD Relationships between VBR and subjective responses to acute intravenous cocaine hydrochloride were examined in 20 male polydrug abusers. Tests were performed in conjunction with positron emission tomography scans to measure cerebral glucose metabolism. RESULTS Subjective measures of effects… CONTINUE READING
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