Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus

@article{Jeffs1997SensitivityTC,
  title={Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus},
  author={Baxter Jeffs and James G. Snake Clark and Niall H. Anderson and Julie Gratton and Mary Julia Brosnan and Dominique Gauguier and John L. Reid and I Mhairi Macrae and Anna F. Dominiczak},
  journal={Nature Genetics},
  year={1997},
  volume={16},
  pages={364-367}
}
Ischaemic stroke is a complex disorder caused by a combination of genetic and environmental factors. Clinical and epidemiological studies have provided strong evidence for genetic influences in the development of human stroke1–3 and several mendelian traits featuring stroke have been described4,5. The genetic analysis of the non-mendelian, common ischaemic stroke in humans is hindered by the late onset of the disease and the mode of inheritance, which is complex, polygenic and multifactorial… CONTINUE READING
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