Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis

@article{Carter1969SensitivityTA,
  title={Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis},
  author={R. Carter},
  journal={Journal of Clinical Pathology},
  year={1969},
  volume={22},
  pages={470 - 474}
}
  • R. Carter
  • Published 1969
  • Biology, Medicine
  • Journal of Clinical Pathology
An amoeba of the genus Naegleria causing fatal meningoencephalitis in a human subject has been investigated for its sensitivity to several drugs. Penicillin, sulphadiazine, chloramphenicol, oxytetracycline hydrochloride, streptomycin, methotrexate, emetine, quinine, and metronidazole had no effect on the organism in vitro at levels in excess of those likely to be attained therapeutically in the brain. Amphotericin B was highly amoebicidal in vitro and protected mice from infection with the… Expand
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  • Biology, Medicine
  • Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 1982
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It is concluded that amphotericin B and ketoconazole remain the main drugs with proven activity against pathogenic Naegleria spp. Expand
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