Sensitivity to DNA-damage induction and chromosomal alterations in mucosa cells from patients with and without cancer of the oropharynx detected by a combination of Comet assay and fluorescence in situ hybridization.

Abstract

In addition to exogenous risk factors, the development of head and neck cancer is based on genetic alterations and individual sensitivity to mutagens. The DNA-damaging effect of xenobiotics and the location of chromosomal changes warrant further investigation. The aim of this study was to evaluate variance in structural genetic changes in human epithelia as… (More)

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@article{Harrus2004SensitivityTD, title={Sensitivity to DNA-damage induction and chromosomal alterations in mucosa cells from patients with and without cancer of the oropharynx detected by a combination of Comet assay and fluorescence in situ hybridization.}, author={Ulrich A. Harr{\'e}us and Norbert Helmut Kleinsasser and Sabina Zieger and Barbara C. Wallner and Max Reiter and Paul Schuller and A. Berghaus}, journal={Mutation research}, year={2004}, volume={563 2}, pages={131-8} }