Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders.

@article{Shepard2016SensitivityOT,
  title={Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders.},
  author={Ryan Michael Shepard and Chloe E Page and L Coutellier},
  journal={Neuroscience},
  year={2016},
  volume={332},
  pages={1-12}
}
Stress-induced modifications of the prefrontal cortex (PFC) are believed to contribute to the onset of mood disorders, such as depression and anxiety, which are more prevalent in women. In depression, the PFC is hypoactive; however the origin of this hypoactivity remains unclear. Possibly, stress could impact the prefrontal GABAergic inhibitory system that… CONTINUE READING