Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens.

@article{Tinwell2004SensitivityOT,
  title={Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens.},
  author={Helen Tinwell and John Ashby},
  journal={Environmental Health Perspectives},
  year={2004},
  volume={112},
  pages={575 - 582}
}
We have evaluated whether mixtures of estrogens, present in the mix at doses that are individually inactive in the immature rat uterotrophic assay, can give a uterotrophic response. Seven chemicals were evaluated: nonylphenol, bisphenol A (BPA), methoxychlor, genistein (GEN), estradiol, diethylstilbestrol, and ethinyl estradiol. Dose responses in the uterotrophic assay were constructed for each chemical. The first series of experiments involved evaluating binary mixtures of BPA and GEN at dose… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

The combined effects of vinclozolin and procymidone do not deviate from expected additivity in vitro and in vivo

IC Nisbet, PK LaGoy
  • Toxicol Sci
  • 2003

An approach for assessing estrogen receptor mediated interactions in mixtures of three chemicals : a pilot study

DG Chen, JG Pounds
  • Toxicol Sci
  • 2002

Combining xeno - estrogens at levels below individual no - observed - effect concentrations dramatically enhances steroid hormone action

TP Rodgers-Gray, S Jobling, +3 authors MJ Waldcock
  • Environ Health Perspect
  • 2002

Something for “ nothing ” — eight weak estrogenic chemicals combined at concentrations below NOEC ’ s produce significant mixture effects

S Takayama, H Hasegawa, H Ohgaki
  • Environ Sci Technol
  • 2002