Sensitivity of the brain transcriptome to connexin ablation.

@article{Iacobas2005SensitivityOT,
  title={Sensitivity of the brain transcriptome to connexin ablation.},
  author={Dumitru Andrei Iacobas and Sanda Iacobaş and M{\'a}rcia Urban-Maldonado and DavidC. Spray},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1711 2},
  pages={
          183-96
        }
}
Extensive studies on mice with total or partial disruption of either connexin43 (Cx43) or connexin32 (Cx32) have detected only subtle changes in central nervous system structure, growth, development, or function. We have used high density cDNA arrays to analyze the regulation, control, and coordination of the abundances of 7446 distinct transcripts in four brains, each of Cx43 null (K43), Cx43 heterozygous (H43), and Cx32 null (K32) mice as compared to the brains of wildtype (W) mice. The use… CONTINUE READING
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