Sensitivity of polarized epithelial cells to the pore-forming toxin aerolysin.

@article{Abrami2003SensitivityOP,
  title={Sensitivity of polarized epithelial cells to the pore-forming toxin aerolysin.},
  author={Laurence Abrami and Marc Fivaz and P. W. Glauser and Nakaba Sugimoto and Chiara Zurzolo and F Gisou van der Goot},
  journal={Infection and immunity},
  year={2003},
  volume={71 2},
  pages={739-46}
}
Aerolysin is one of the major virulence factors produced by Aeromonas hydrophila, a human pathogen that produces deep wound infection and gastroenteritis. The toxin interacts with target mammalian cells by binding to the glycan core of glycosylphosphatidyl inositol (GPI)-anchored proteins and subsequently forms a pore in the plasma membrane. Since epithelial cells of the intestine are the primary targets of aerolysin, we investigated its effect on three types of polarized epithelial cells: Caco… CONTINUE READING

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