Sensitivity of nucleotide excision repair-deficient human cells to ionizing radiation and cyclophosphamide.

@article{Murray2002SensitivityON,
  title={Sensitivity of nucleotide excision repair-deficient human cells to ionizing radiation and cyclophosphamide.},
  author={David L. Murray and Loretta Vallee-Lucic and Elizabeth Rosenberg and Borje S. Andersson},
  journal={Anticancer research},
  year={2002},
  volume={22 1A},
  pages={
          21-6
        }
}
Nucleotide excision repair (NER)-deficient rodent and human cells (such as those derived from patients with xeroderma pigmentosum, XP) are hypersensitive to UV light. Some of these cell lines, specifically certain rodent mutants with severe defects in the ERCC1 and XPF genes, are dramatically sensitive to crosslinking agents such as phosphoramide mustard (PM). These crosslink-sensitive rodent mutants also exhibit sensitization to gamma-rays under hypoxic (but not under aerated) conditions. Like… CONTINUE READING

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