Sensitivity of mesenchymal stem cells and their progeny to medicines used for the treatment of hematoproliferative diseases.

Abstract

BACKGROUND/AIMS The influence of cytostatic medicines on mesenchymal stem cells (MSC) and their progeny, fibroblastic colony-forming units (CFU-F), was investigated. METHODS Mice were treated with busulfan, cyclophosphamide, cytarabine, methotrexate and bortezomib, as used in clinical practice. MSC and CFU-F were analyzed 3 days and 6 weeks after the… (More)
DOI: 10.1159/000120440

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