Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.

@article{Kharasch2011SensitivityOI,
  title={Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.},
  author={Evan D. Kharasch and Awah Francis and Amy E London and Konstantin Frey and Taekrho Kim and Jane Blood},
  journal={Clinical pharmacology and therapeutics},
  year={2011},
  volume={90 1},
  pages={100-8}
}
Systemic and oral clearances of alfentanil (ALF) are in vivo probes for hepatic and first-pass cytochrome P450 (CYP) 3A. Both ALF single-point plasma concentrations and miosis are surrogates for area under the concentration-time curve (AUC) and clearance and are minimal and noninvasive CYP3A probes. This investigation determined ALF sensitivity for detecting graded CYP3A induction and compared it with that of midazolam (MDZ). Twelve volunteers (sequential crossover) received 0, 5, 10, 25, or 75… CONTINUE READING

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