Sensitivity of immunocytochemical detection of breast cancer cells in human bone marrow.

@article{Osborne1991SensitivityOI,
  title={Sensitivity of immunocytochemical detection of breast cancer cells in human bone marrow.},
  author={Michael P. Osborne and Gilbert Y. Wong and Shirin Asina and L. John Old and Richard J. Cote and Paul Peter Rosen},
  journal={Cancer research},
  year={1991},
  volume={51 10},
  pages={2706-9}
}
We have previously shown that occult micrometastases can be detected in the bone marrow of breast cancer patients, at the time of initial treatment, using a panel of epithelial specific monoclonal antibodies indirectly labeled with fluorescein. These monoclonal antibodies permit us to detect cancer cells at at concentration of two/million normal bone marrow cells. Immunofluorescence carries the disadvantage that detailed morphological examination of detected cells cannot be accomplished. A… CONTINUE READING