Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites.

@article{Han2004SensitivityOH,
  title={Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites.},
  author={Jian-Qiu Han and Gerggory Wroblewski and Zan Xu and Robert H. Silverman and David J. Barton},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2004},
  volume={24 11},
  pages={664-76}
}
Ribonuclease L (RNase L) cleaves RNA predominantly at single-stranded UA and UU dinucleotides. Intriguingly, hepatitis C virus (HCV) RNAs have a paucity of UA and UU dinucleotides, and relatively interferon (IFN)-resistant strains have fewer UA and UU dinucleotides than do more IFN-sensitive strains. In this study, we found that contextual features of UA and UU dinucleotides dramatically affected the efficiency of RNase L cleavage in HCV RNA. HCV genotype la RNA was cleaved by RNase L into… CONTINUE READING