Sensitivity of activated human lymphocytes to cyclosporine and its metabolites.

  title={Sensitivity of activated human lymphocytes to cyclosporine and its metabolites.},
  author={Adriana Zeevi and Raman Venkataramanan and Gilbert J. Burckart and C. P. Wang and Noriko Murase and David H. van Thiel and Thomas E. Starzl and Leonard Makowka and Ren{\'e} J. Duquesnoy},
  journal={Human immunology},
  volume={21 2},
Alloreactive T cells generated as clones from mixed lymphocyte cultures, or propagated from heart or liver transplant biopsies, were tested for secondary proliferation measured in the primed lymphocyte test in the presence of Cyclosporine A and metabolites fractionated from human bile. Significant differences were observed in Cyclosporine A sensitivity between various cell cultures ranging as high as 100-fold. The liver is the primary site of Cyclosporine A metabolism, which yields a number of… CONTINUE READING