Sensitivity of DNA and nucleotides to oxidation by permanganate and hydrogen peroxide.

Abstract

Fora number of cytotoxic and tumorigenic agents, active oxygen species such as hydroxyl radical are postulated to be responsible for indirect DNA darnage (Cerutti 1981). Besides the formation of strand breaks, hydroxylation of DNA bases is assumed to occur, as sha.wn earlier with ionizing radiation. It was the aim of this work to determine in vitro the DNA… (More)

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