Sensitivity of Cancer Cells to Truncated Diphtheria Toxin

Abstract

BACKGROUND Diphtheria toxin (DT) has been utilized as a prospective anti-cancer agent for the targeted delivery of cytotoxic therapy to otherwise untreatable neoplasia. DT is an extremely potent toxin for which the entry of a single molecule into a cell can be lethal. DT has been targeted to cancer cells by deleting the cell receptor-binding domain and… (More)
DOI: 10.1371/journal.pone.0010498

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