Sensitivity of Bloom syndrome fibroblasts to mitomycin C.

  title={Sensitivity of Bloom syndrome fibroblasts to mitomycin C.},
  author={Graham J Hook and Edmund Kwok and John A. Heddle},
  journal={Mutation research},
  volume={131 5-6},
Lymphocytes and fibroblasts from people with Bloom syndrome, an autosomal recessive disorder associated with a predisposition to a wide variety of cancers, are known to be hypersensitive to ethylating agents as measured by sister chromatid exchange induction. Recently, hypersensitivity to cell killing by mitomycin C has also been reported in Bloom syndrome fibroblasts from three donors. We report here results which confirm the hypersensitivity of Bloom syndrome fibroblasts as measured by cell… CONTINUE READING

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