Sensitivity and selectivity of ricin toxin A chain-monoclonal antibody 791T/36 conjugates against human tumor cell lines.

@article{Embleton1986SensitivityAS,
  title={Sensitivity and selectivity of ricin toxin A chain-monoclonal antibody 791T/36 conjugates against human tumor cell lines.},
  author={Michael J. Embleton and VeraS. Byers and Hwan Myung Lee and Patrick J. Scannon and N. W. Blackhall and Robert W. Baldwin},
  journal={Cancer research},
  year={1986},
  volume={46 11},
  pages={
          5524-8
        }
}
Ricin toxin A chain (RTA) was conjugated to monoclonal antibody 791T/36, which was raised originally against human osteogenic sarcoma cell line 791T. The resultant conjugates were characterized and tested for cytotoxicity against a panel of human tumor cell lines representing a defined range of antigenicity with regard to 791T/36. Conjugates were highly cytotoxic for cells expressing high antigen density, inhibiting cell survival at RTA concentrations three to four orders of magnitude lower… CONTINUE READING

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Antibody targeting of anti-cancer agents

M. J. Embleton, C C¡arm-it.M.
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