# Sensitivity and network topology in chemical reaction systems.

@article{Okada2017SensitivityAN, title={Sensitivity and network topology in chemical reaction systems.}, author={Takashi Okada and Atsushi Mochizuki}, journal={Physical review. E}, year={2017}, volume={96 2-1}, pages={ 022322 } }

In living cells, biochemical reactions are catalyzed by specific enzymes and connect to one another by sharing substrates and products, forming complex networks. In our previous studies, we established a framework determining the responses to enzyme perturbations only from network topology, and then proved a theorem, called the law of localization, explaining response patterns in terms of network topology. In this paper, we generalize these results to reaction networks with conserved…

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