Sensitive determination of buprenorphine and its N-dealkylated metabolite norbuprenorphine in human plasma by liquid chromatography coupled to tandem mass spectrometry.

Abstract

A highly sensitive method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the quantitative determination of buprenorphine and its active metabolite norbuprenorphine in human plasma. Automated solid phase extraction (SPE) on disposable extraction cartridges (DEC) is used to isolate the compounds from the biological… (More)

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Cite this paper

@article{Ceccato2003SensitiveDO, title={Sensitive determination of buprenorphine and its N-dealkylated metabolite norbuprenorphine in human plasma by liquid chromatography coupled to tandem mass spectrometry.}, author={Attilio Ceccato and R{\'e}gis Klinkenberg and P H Hubert and Bruno Streel}, journal={Journal of pharmaceutical and biomedical analysis}, year={2003}, volume={32 4-5}, pages={619-31} }