Sensitive determination method of estradiol in plasma using high-performance liquid chromatography with electrochemical detection.

@article{Yamada2002SensitiveDM,
  title={Sensitive determination method of estradiol in plasma using high-performance liquid chromatography with electrochemical detection.},
  author={Hiroyuki Yamada and Katsuyoshi Yoshizawa and Tetsuo Hayase},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2002},
  volume={775 2},
  pages={209-13}
}
The improvement in the sensitive determination method of estradiol using HPLC with electrochemical detection is described. The improvement was due to the optimization of the potential applied to the electrode of the analytical cell and employment of a guard cell. The detection conditions were optimized from the electrochemical properties of estradiol in acidic and alkaline eluents. The employment of the guard cell drastically decreased the background noise without any reduction in the response… CONTINUE READING

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