Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies.

@article{Yang2005SensitiveDO,
  title={Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies.},
  author={Hanwenbo Yang and K. Yang and Ahmed Khafagi and Y Tang and Thomas E. Carey and Anthony Opipari and Rita Lieberman and Paul A Oeth and Warren Lancaster and Harold P. Klinger and Ahmed Kaseb and Alaa Metwally and Habib Khaled and David M. Kurnit},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 21},
  pages={7683-8}
}
We assayed for the presence of human papilloma virus (HPV) DNA in serum and/or peripheral blood fraction (PBF) of individuals with cervical, head/neck, or bladder cancer due to schistosomiasis. Using mass spectroscopy coupled with competitive PCR, HPV DNA was detected at the individual molecule level by using "MassARRAY" assays. The resultant sensitivity was superior to real-time fluorescent PCR-based assays, while specificity was maintained. Our principal findings were: (i) Virtually all… CONTINUE READING

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