Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptibility to protease, reverse transcriptase, integrase, and maturation inhibitors, as well as HIV-1 coreceptor tropism.

@article{Gibson2014SensitiveDH,
  title={Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptibility to protease, reverse transcriptase, integrase, and maturation inhibitors, as well as HIV-1 coreceptor tropism.},
  author={Richard M. Gibson and Ashley M Meyer and Dane Winner and John W. Archer and Felix Feyertag and Ezequiel Ruiz-mateos and Manuel Leal and David L. Robertson and Christine L Schmotzer and Miguel E Qui{\~n}ones-Mateu},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 4},
  pages={2167-85}
}
With 29 individual antiretroviral drugs available from six classes that are approved for the treatment of HIV-1 infection, a combination of different phenotypic and genotypic tests is currently needed to monitor HIV-infected individuals. In this study, we developed a novel HIV-1 genotypic assay based on deep sequencing (DeepGen HIV) to simultaneously assess HIV-1 susceptibilities to all drugs targeting the three viral enzymes and to predict HIV-1 coreceptor tropism. Patient-derived gag-p2/NCp7… CONTINUE READING
26 Citations
118 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 118 references

An Enhanced-Sensitivity TrofileTM HIV 747 Coreceptor Tropism Assay for Selecting Patients for Therapy with Entry Inhibitors Targeting CCR5: A 748 Review of Analytical and Clinical Studies

  • JD Reeves, E Coakley, CJ Petropoulos, JM. Whitcomb
  • Journal of Viral Entry
  • 2009
Highly Influential
11 Excerpts

Similar Papers

Loading similar papers…