Sensitive cell apoptosis assay based on caspase-3 activity detection with graphene oxide-assisted electrochemical signal amplification.

@article{Chen2015SensitiveCA,
  title={Sensitive cell apoptosis assay based on caspase-3 activity detection with graphene oxide-assisted electrochemical signal amplification.},
  author={Hongxia Chen and Jiangjiang Zhang and Yanmin Gao and Siyu Liu and K. Koh and Xiaoli Zhu and Yongmei Yin},
  journal={Biosensors \& bioelectronics},
  year={2015},
  volume={68},
  pages={
          777-782
        }
}
This paper reports a novel approach for the simple assays of cell apoptosis using electrochemical technique. In this study, caspase-3 activity, which was detected with differential plus voltammetry (DPV) as an alternative to conventional spectrometry approach, was employed as an indicator of cell apoptosis and, while an acetylated peptide Ac-GGHDEVDHGGGC was used as the blocked substrate. In the presence of casepase-3, the hydrolysis of blocked peptide might release active amine groups, which… Expand
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A novel absorption spectrometric method, based on graphene nanomaterials, for detection of hepatocellular carcinoma-specific T lymphocyte cells
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