Sensitive assay for determination of hydroxyzine in plasma and its human pharmacokinetics.


An assay suitable for hydroxyzine determination in human plasma following therapeutic doses was developed. The method involves GLC and chemical-ionization mass spectrometry of the acetate derivatives of hydroxyzine and of a pentadeuterated analog internal standard. Following administration of 100-mg single oral doses to normal male volunteers, peak plasma… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.