Sensitive and selective liquid chromatography-electrospray ionization mass spectrometry analysis of ginkgolide B in dog plasma.

@article{Hua2006SensitiveAS,
  title={Sensitive and selective liquid chromatography-electrospray ionization mass spectrometry analysis of ginkgolide B in dog plasma.},
  author={Lv Zhen Hua and Wang Guangji and Li Hao and Huang Minwen and Xie Haitang and Huang Chenrong and Sun Jianguo and Lv Tian},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2006},
  volume={40 1},
  pages={88-94}
}
As an important active constituent of Ginkgo biloba extract, ginkoglide B is a highly selective and competitive PAF receptor antagonist which has been widely used in clinical applications. A novel high-performance liquid chromatography-electrospray ionization mass spectromentry (LC-ESI-MS) method was developed for the determination of ginkgolide B in dog plasma. After liquid/liquid extraction with ether and high-performance liquid chromatography (HPLC) gradient separation with 0.01% of ammonia… CONTINUE READING

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