Sensitive and selective liquid chromatographic assay of memantine in plasma with fluorescence detection after pre-column derivatization.

@article{Suckow1999SensitiveAS,
  title={Sensitive and selective liquid chromatographic assay of memantine in plasma with fluorescence detection after pre-column derivatization.},
  author={Raymond F. Suckow and Ming Feng Zhang and Elaine D Collins and Marian W. Fischman and Thomas B. Cooper},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={1999},
  volume={729 1-2},
  pages={217-24}
}
A procedure was developed for the determination of memantine in plasma using liquid chromatography with fluorescence detection. Following a liquid-liquid extraction from 1 ml of plasma containing the internal standard amantadine, the extract was derivatized at room temperature with dansyl chloride, and the highly fluorescent derivatives were chromatographed… CONTINUE READING