Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum.

@article{Lehnert1996SensitiveAR,
  title={Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum.},
  author={Megan Lehnert and Rita de Giuli and Peter R. Twentyman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1996},
  volume={2 2},
  pages={403-10}
}
Clinical studies of agents capable of reversing P-glycoprotein (Pgp)-mediated multidrug resistance have attracted much attention in recent years. One question of interest in such studies is whether the concentrations achieved by chemosensitizers are sufficient to inhibit Pgp function. The goal of the present study was to develop a reliable ex vivo bioassay for analysis of the Pgp-inhibiting activity of chemosensitizer-containing patient serum. The fluorescent Pgp substrates daunorubicin (DNR… CONTINUE READING

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