Sensitive and Precise Quantification of Insulin-Like mRNA Expression in Caenorhabditis elegans

@inproceedings{Baugh2011SensitiveAP,
  title={Sensitive and Precise Quantification of Insulin-Like mRNA Expression
                    in Caenorhabditis elegans},
  author={L Ryan Baugh and Nicole Kurhanewicz and Paul W. Sternberg},
  booktitle={PloS one},
  year={2011}
}
Insulin-like signaling regulates developmental arrest, stress resistance and lifespan in the nematode Caenorhabditis elegans. However, the genome encodes 40 insulin-like peptides, and the regulation and function of individual peptides is largely uncharacterized. We used the nCounter platform to measure mRNA expression of all 40 insulin-like peptides as well as the insulin-like receptor daf-2, its transcriptional effector daf-16, and the daf-16 target gene sod-3. We validated the platform using… CONTINUE READING
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