Sensitive amperometric immunosensing using polypyrrolepropylic acid films for biomolecule immobilization.

  title={Sensitive amperometric immunosensing using polypyrrolepropylic acid films for biomolecule immobilization.},
  author={Hua Dong and Chang Ming Li and Wei Chen and Qin Zhou and Zhaohui Zeng and John H. T. Luong},
  journal={Analytical chemistry},
  volume={78 21},
An electrochemical immunosensor was constructed using an electropolymerized pyrrolepropylic acid (PPA) film with high porosity and hydrophilicity. A high density of carboxyl groups of PPA was used to covalently attach protein probes, leading to significantly improved detection sensitivity compared with conventional entrapment methods. As a model, anti-mouse IgG was covalently immobilized or entrapped in the PPA film and used in a sandwich-type alkaline phosphatase-catalyzing amperometric… 

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