Sensitisation of visceral afferents by nerve growth factor in the adult rat

@article{Dmitrieva1996SensitisationOV,
  title={Sensitisation of visceral afferents by nerve growth factor in the adult rat},
  author={Natalia Dmitrieva and Stephen B. McMahon},
  journal={Pain},
  year={1996},
  volume={66},
  pages={87-97}
}
Since there is growing evidence that nerve growth factor (NGF) acts as a mediator of persistent pain states, here we have studied its acute effects on the properties of primary afferent neurones innervating adult rat urinary bladder. Single A delta and C fibres were dissected from the L6 or S1 dorsal roots of urethane anaesthetized rats. The stimulus-response function of these afferents was evaluated with a series of isotonic distensions of the bladder (0-60 cm H2O). The afferents were then… CONTINUE READING

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