Sensitisation of visceral afferents by nerve growth factor in the adult rat

  title={Sensitisation of visceral afferents by nerve growth factor in the adult rat},
  author={Natalia Dmitrieva and Stephen B. McMahon},
Since there is growing evidence that nerve growth factor (NGF) acts as a mediator of persistent pain states, here we have studied its acute effects on the properties of primary afferent neurones innervating adult rat urinary bladder. Single A delta and C fibres were dissected from the L6 or S1 dorsal roots of urethane anaesthetized rats. The stimulus-response function of these afferents was evaluated with a series of isotonic distensions of the bladder (0-60 cm H2O). The afferents were then… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 74 extracted citations

Craniofacial pain and motor function: pathogenesis, clinical correlates, and implications.

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists • 1999
View 9 Excerpts
Highly Influenced

The induction of pain: an integrative review

Progress in Neurobiology • 1999
View 13 Excerpts
Highly Influenced

Therapeutic receptor targets for lower urinary tract dysfunction

Naunyn-Schmiedeberg's Archives of Pharmacology • 2007
View 4 Excerpts
Highly Influenced

The involvement of the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3/SNS) in a rat model of visceral pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2001
View 6 Excerpts
Highly Influenced

PACAP/PAC1 Expression and Function in Micturition Pathways

Journal of Molecular Neuroscience • 2018
View 2 Excerpts

Similar Papers

Loading similar papers…