Sensitisation of spinal cord pain processing in medication overuse headache involves supraspinal pain control.

@article{Perrotta2010SensitisationOS,
  title={Sensitisation of spinal cord pain processing in medication overuse headache involves supraspinal pain control.},
  author={Armando Perrotta and Mariano Serrao and Giorgio Sandrini and Rami Burstein and Grazia Sances and Paolo Rossi and Michelangelo Bartolo and Francesco Pierelli and Giuseppe Nappi},
  journal={Cephalalgia : an international journal of headache},
  year={2010},
  volume={30 3},
  pages={272-84}
}
Medication overuse could interfere with the activity of critical brain regions involved in the supraspinal control of pain signals at the trigeminal and spinal level, leading to a sensitisation phenomenon responsible for chronic pain. We hypothesised that medication-overuse headache (MOH) patients might display abnormal processing of pain stimuli at the spinal level and defective functioning of the diffuse noxious inhibitory controls. We tested 31 MOH patients before (bWT) and after (aWT… CONTINUE READING
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