Sensitisation of articular afferents in normal and inflamed knee joints by substance P in the rat.

@article{Heppelmann1997SensitisationOA,
  title={Sensitisation of articular afferents in normal and inflamed knee joints by substance P in the rat.},
  author={Bernd Heppelmann and Matthias Pawlak},
  journal={Neuroscience letters},
  year={1997},
  volume={223 2},
  pages={97-100}
}
To examine whether substance P (SP) influences the response properties of fine articular afferents in normal and acutely inflamed joints, single units were recorded from the rat knee during normal and noxious joint rotations. Only three of 39 units were activated by a single bolus injection of 0.1 mM SP. However, 35% (7/20) of the nerve fibres from the normal joint and 21% (4/19) of the units from the inflamed joint significantly increased their responses to movements after the SP injection… CONTINUE READING

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