Sensing substrate rigidity by mechanosensitive ion channels with stress fibers and focal adhesions.

@article{Kobayashi2010SensingSR,
  title={Sensing substrate rigidity by mechanosensitive ion channels with stress fibers and focal adhesions.},
  author={Takeshi Kobayashi and Masahiro Sokabe},
  journal={Current opinion in cell biology},
  year={2010},
  volume={22 5},
  pages={669-76}
}
Cell motility, spreading, proliferation and differentiation are critically influenced by substrate rigidity. To sense substrate rigidity, cells apply traction forces to cell-substrate adhesions via actin stress fibers (SFs) and measure mechanical responses of the substrate. Besides mechanosensitive adaptor proteins, mechanosensitive (MS) channels are involved in the substrate rigidity sensing. MS channels located at or near focal adhesions (FAs) convert the rigidity-dependent stress generated… CONTINUE READING

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