Sensing of intermediates in V(D)J recombination by ATM.

  title={Sensing of intermediates in V(D)J recombination by ATM.},
  author={Eric J Perkins and Ayyappan Nair and Dale O Cowley and Terry Van Dyke and Yung Chang and Dale A Ramsden},
  journal={Genes & development},
  volume={16 2},
Ataxia-telangiectasia mutated (ATM) is required for resistance to radiation-induced DNA breaks. Here we use chromatin immunoprecipitation to show that ATM also localizes to breaks associated with V(D)J recombination. ATM recruitment to the recombining locus correlates approximately with recruitment of the break-initiating factor RAG1 and precedes efficient break repair, consistent with localization of ATM to normal recombination intermediates. A product of ATM kinase activity, Ser 18… CONTINUE READING

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