Sensing of bacteria: NOD a lonely job.

  title={Sensing of bacteria: NOD a lonely job.},
  author={Thomas A Kufer and Philippe J Sansonetti},
  journal={Current opinion in microbiology},
  volume={10 1},
Recognition of bacteria by the vertebrate innate immune system relies on detection of invariant molecules by specialized receptors. The view is emerging that activation of both Toll-like receptors (TLRs) and Nod-like receptors (NLRs) by different bacterial agonists is important in order to mount an inflammatory response in the host. Priming of cells with peptidoglycan and products that are sensed by cytosolic-localized members of the NLR family have a synergistic effect on TLR signalling and… CONTINUE READING

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