Sensing damage by the NLRP3 inflammasome.

  title={Sensing damage by the NLRP3 inflammasome.},
  author={Jaklien C Leemans and Suzanne L. Cassel and Fayyaz Shiraz Sutterwala},
  journal={Immunological reviews},
  volume={243 1},
The NLRP3 inflammasome is activated in response to a variety of signals that are indicative of damage to the host including tissue damage, metabolic stress, and infection. Upon activation, the NLRP3 inflammasome serves as a platform for activation of the cysteine protease caspase-1, which leads to the processing and secretion of the proinflammatory… CONTINUE READING