Sensing and responding to hypoxia via HIF in model invertebrates.

  title={Sensing and responding to hypoxia via HIF in model invertebrates.},
  author={Thomas A Gorr and Max Gassmann and Pablo Wappner},
  journal={Journal of insect physiology},
  volume={52 4},
This past decade has brought considerable progress towards elucidating the molecular mechanisms of oxygen sensing pathways by which mammalian cells are able to detect and adjust, or succumb, to hypoxia. In contrast, far less is known about the protein and DNA constituents that endow many invertebrate species to withstand and recover from even more severe and prolonged O2 limitations. In spite of these differences in hypoxia tolerance, inadequacy in oxygen supply is, from mammals to insects to… CONTINUE READING


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