Sensing and responding to energetic stress: The role of the AMPK-PGC1α-NRF1 axis in control of mitochondrial biogenesis in fish.

@article{Bremer2016SensingAR,
  title={Sensing and responding to energetic stress: The role of the AMPK-PGC1α-NRF1 axis in control of mitochondrial biogenesis in fish.},
  author={Katharina Bremer and Katrinka M Kocha and T. G. Snider and Christopher D Moyes},
  journal={Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology},
  year={2016},
  volume={199},
  pages={4-12}
}
Remodeling the muscle metabolic machinery in mammals in response to energetic challenges depends on the energy sensor AMP-activated protein kinase (AMPK) and its ability to phosphorylate PPAR γ coactivator 1 α (PGC1α), which in turn coactivates metabolic genes through direct and indirect association with DNA-binding proteins such as the nuclear respiratory factor 1 (NRF1) (Wu et al., 1999). The integrity of this axis in fish is uncertain because PGC1α i) lacks the critical Thr177 targeted by… CONTINUE READING

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