Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations.

@article{He2018SensingAT,
  title={Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations.},
  author={Xia-Di He and Wei Gong and Jia-nong Zhang and Ji Nie and Cui-Fang Yao and Fu-Shen Guo and Yan Lin and Xiao-Hui Wu and Q Ping Dou and Jie Li and Wei-Cheng Sun and En-Duo Wang and Yan-Peng An and Hui-Ru Tang and Guo-quan Yan and Pengyuan Y. Yang and Yun Yi Wei and Yun-Zi Mao and Peng-cheng Lin and Jian-yuan Zhao and Yanhui Xu and Wei Xu and Shi-min Zhao},
  journal={Cell metabolism},
  year={2018},
  volume={27 1},
  pages={151-166.e6}
}
Amino acids are known regulators of cellular signaling and physiology, but how they are sensed intracellularly is not fully understood. Herein, we report that each aminoacyl-tRNA synthetase (ARS) senses its cognate amino acid sufficiency through catalyzing the formation of lysine aminoacylation (K-AA) on its specific substrate proteins. At physiologic levels, amino acids promote ARSs bound to their substrates and form K-AAs on the ɛ-amine of lysines in their substrates by producing reactive… CONTINUE READING
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