Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL.

@article{Hirano2011SensingAD,
  title={Sensing actin dynamics: structural basis for G-actin-sensitive nuclear import of MAL.},
  author={Hidemi Hirano and Yoshiyuki Matsuura},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={414 2},
  pages={
          373-8
        }
}
The coordination of cytoskeletal actin dynamics with gene expression reprogramming is emerging as a crucial mechanism to control diverse cellular processes, including cell migration, differentiation and neuronal circuit assembly. The actin-binding transcriptional coactivator MAL (also known as MRTF-A/MKL1/BSAC) senses G-actin concentration and transduces Rho GTPase signals to serum response factor (SRF). MAL rapidly shuttles between the cytoplasm and the nucleus in unstimulated cells but Rho… CONTINUE READING

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