Sensing Small Molecules by Nascent RNA A Mechanism to Control Transcription in Bacteria

@article{Mironov2002SensingSM,
  title={Sensing Small Molecules by Nascent RNA A Mechanism to Control Transcription in Bacteria},
  author={Alexander Mironov and Ivan Gusarov and Ruslan Rafikov and Lubov Errais Lopez and Konstantin Shatalin and Rimma A. Kreneva and Daniel A. Perumov and Vladimir Svetlov},
  journal={Cell},
  year={2002},
  volume={111},
  pages={747-756}
}
Thiamin and riboflavin are precursors of essential coenzymes-thiamin pyrophosphate (TPP) and flavin mononucleotide (FMN)/flavin adenine dinucleotide (FAD), respectively. In Bacillus spp, genes responsible for thiamin and riboflavin biosynthesis are organized in tightly controllable operons. Here, we demonstrate that the feedback regulation of riboflavin and thiamin genes relies on a novel transcription attenuation mechanism. A unique feature of this mechanism is the formation of specific… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 193 extracted citations

Prospects for riboswitch discovery and analysis.

Molecular cell • 2011
View 17 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Biosynthesis of riboflavin , biotin , folic acid , and cobalamin

J. B. Perkins, J. Pero
Bacillus Subtillis and Its Closest Relatives : from Genes to Cells • 2002
View 3 Excerpts
Highly Influenced

A conserved RNA structure (thi box) is involved in regulation of thiamin biosynthetic gene expression in bacteria.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 5 Excerpts
Highly Influenced

Do mRNAs act as direct sensors of small molecules to control their expression?

Proceedings of the National Academy of Sciences of the United States of America • 2001

Adenosylcobalamin inhibits ribosome binding to btuB RNA.

Proceedings of the National Academy of Sciences of the United States of America • 2000

Transcription termination control in bacteria.

Current opinion in microbiology • 2000

Similar Papers

Loading similar papers…