Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

@article{Johmura2021SenolysisBG,
  title={Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders},
  author={Yoshikazu Johmura and Takehiro Yamanaka and Satotaka Omori and Teh-Wei Wang and Yuki Sugiura and Masaki Matsumoto and Narumi Suzuki and Soichiro Kumamoto and Kiyoshi Yamaguchi and Seira Hatakeyama and Tomoyo Takami and Rui Yamaguchi and Eigo Shimizu and Kazutaka Ikeda and Nobuyuki Okahashi and Ryuta Mikawa and Makoto Suematsu and Makoto Arita and Masataka Sugimoto and Keiichi I. Nakayama and Yoichi Furukawa and Seiya Imoto and Makoto Nakanishi},
  journal={Science},
  year={2021},
  volume={371},
  pages={265 - 270}
}
Selective destruction of senescent cells Senescent cells are associated with a variety of age-related medical conditions and thus have been proposed as potential targets for therapy, but we do not yet have a full understanding of the underlying mechanisms. Johmura et al. used RNA interference to screen for enzymes essential to the survival of senescent cells (see the Perspective by Pan and Locasale). The authors identified a key role for glutamine metabolism, particularly the enzyme glutaminase… Expand
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