Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.

Abstract

In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as well as parameters of hepato- and nephrotoxicity were observed.

Cite this paper

@article{Siegers1993SennosidesAA, title={Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.}, author={C P Siegers and J Siemers and G Baretton}, journal={Pharmacology}, year={1993}, volume={47 Suppl 1}, pages={205-8} }