Senile plaque-like structures: observation of a probably unknown type of senile plaque by periodic-acid methenamine silver (PAM) electron microscopy

@article{Ikeda1989SenilePS,
  title={Senile plaque-like structures: observation of a probably unknown type of senile plaque by periodic-acid methenamine silver (PAM) electron microscopy},
  author={Kazuhiko Ikeda and Catherine Haga and Kenji Kosaka and Shinsaku Oyanagi},
  journal={Acta Neuropathologica},
  year={1989},
  volume={78},
  pages={137-142}
}
Numerous diffuse senile plaque-like structures (SPLSs) were found in the cerebral cortex from cases with dementia of the Alzheimer type by means of the methenamine-Bodian method. SPLSs varied in shape and size. They were never recognized in the original Bodian, PAS and Congo red preparations, but were positive with anti-β-protein immunostaining and periodic-acid methenamine silver (PAM) methods, which are thought to specifically stain amyloid substance. With PAM electron microscopy, we found… CONTINUE READING
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