Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair.

@article{Wood2009SenileHG,
  title={Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair.},
  author={John P. M. Wood and Helena Decker and H. Hartmann and Bhaven Chavan and Hartmut Rokos and Jennifer D Spencer and Sybille Hasse and M. Julie Thornton and Mohammad Shalbaf and Ralf Paus and Karin Uta Schallreuter},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 7},
  pages={2065-75}
}
Senile graying of human hair has been the subject of intense research since ancient times. Reactive oxygen species have been implicated in hair follicle melanocyte apoptosis and DNA damage. Here we show for the first time by FT-Raman spectroscopy in vivo that human gray/white scalp hair shafts accumulate hydrogen peroxide (H(2)O(2)) in millimolar concentrations. Moreover, we demonstrate almost absent catalase and methionine sulfoxide reductase A and B protein expression via immunofluorescence… CONTINUE READING
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